An all-woman team of four PhDs, are working to correct the narratives surrounding modern anti-aging skincare: that we should treat our skin with a longevity-first approach, prioritizing its long-term health over its appearance. Carolina Reis Olivera, Alessandra Zonari, Mariana Boroni, and Juliana Lott founded OneSkin after discovering that many anti-aging skincare products are not only ineffective, but often even accelerate the aging process and compromise skin’s health. That’s what set them on a mission to develop products that target skin aging and its effects at a molecular level, all while reframing the way we think about skin -not just for appearance, but as a functional and integral contributor to our long-term health.
In 2016, OneSkin was founded as a research company to test the efficacy of everyday topical skincare products using an in-house-developed proprietary algorithm that can accurately predict skin’s biological age, called MolClock. After uncovering the shocking results that many “anti-aging” products actually accelerate the aging process, they used their lab-based research platform to develop a proprietary peptide called OS-01 that, unlike most products and ingredients on the market, is able to reduce the biological age of skin (shown in ex vivo human skin models using MolClock). Using human skin models, the scientific team was able to show that the OS-01 peptide improves the overall health of the skin by preventing the accumulation of senescent, or aging, cells and promoting molecular repair mechanisms which, in turn, increases epidermal thickness and promotes collagen production (shown in in vitro skin cells and ex vivo skin models). As a result, the four women launched their flagship product, OS-01 FACE, in February 2021 to solve an old problem with an entirely new approach.
While OneSkin offers a line of premiere skin health products with rave reviews that aim to address the root causes of skin aging, the brand chooses to celebrate aging and focus on maintaining the health of the skin over time rather than dwelling on its appearance. It just so happens that by first catering to the overall health of the skin, the appearance also drastically improves. OneSkin is one of the first companies in the beauty space to recognize skin as the body’s largest organ and first defense against external stressors, making it an active part of systemic longevity. OS-01 FACE is OneSkin’s flagship product and the first of its kind to address the root cause of skin aging on a molecular level, developed for skin most exposed to damage on the face, neck, and decolletage. It is clinically validated to promote skin strength, elasticity, and barrier function and ultimately minimizes the appearance of wrinkles (shown in a 12-week clinical study performed by a third-party CRO). OS-01 BODY is the complementary product that, like OS-01 FACE, focuses on improving the health of your skin, but on skin below the neck. It is meant to be used as a daily moisturizer and designed specifically for the body’s skin. OS-01 BODY improves overall hydration, reduces flakiness, and boosts the smoothness of the skin. PREP Cleanser is the first step of the OneSkin regimen that is made to prepare your skin to absorb the active ingredients found in OS-01 FACE, particularly the OS-01 peptide. It gently exfoliates and removes impurities to ready the skin without the drying or irritating effects of an average cleanser.
By creating innovative products and continually developing and supporting their own research, OneSkin is on a mission to become the leading longevity platform for skincare. As scientists, they let data guide everything that they do, boldly challenging the status quo when the data supports it. OneSkin is the first skincare brand to develop products that target a central part of the aging process, cellular senescence. By developing scientifically-validated, highly effective, and safe products that address aging at the source, OneSkin is setting a new standard in the beauty industry, prioritizing the health of skin and experiencing improved appearance as a result.
OneSkin has only been gaining more recognition within the cosmetic, functional health, and medical fields and expanding its own scientific realm since its launch in 2021. The brand has been featured in Tony Robbins book, “Life Force,” as one of the newest breakthroughs in medical science today. World-renowned aging research doctor David Sinclair made a notable mention of the brand as well in a “LifeSpan” podcast episode that focused on scientific research directed towards looking younger for longer. Dave Asprey, a foremost authority on biohacking, mentioned OneSkin’s technology as well in his podcast “The Human Upgrade,” where he focused on how exactly a peptide can effectively combat the root cause of aging.
Their most recent development, OS-01 EYE, is formulated with the highest concentration of the OS-01 peptide and is the first of its kind, as it has been tested on ex vivo skin cultured from human eyelid cells. OS-01 EYE addresses the unique needs of the ultra-delicate skin around the eyes, helping to strengthen, firm, and increase resistance to signs of aging such as sagging, crow’s feet, wrinkles, and puffiness. Be sure to mark your calendar for the February 28th launch of OS-01 EYE.
In a society that tries to reduce skin’s purpose to be a mere window dressing for our bodies, OneSkin has flipped the script, encouraging us to approach skin health holistically and embrace aging with less fear and more empowerment to live life to our fullest potential.
